Carpal Tunnel Syndrome - Two Commonly Misdiagnosed Conditions

Dr. Carlo Neri
April 6, 2025

Have Questions About This Article?

Experiencing hand pain, numbness, or tingling? You may assume it's carpal tunnel syndrome (CTS), but that's not always the case. Several other medical conditions can produce similar symptoms. Misdiagnosis can delay proper treatment, worsening your condition. We'll cover two frequently misdiagnosed disorders that often resemble CTS: arthritis and cubital tunnel syndrome.

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Table of Contents

What Is Carpal Tunnel Syndrome?
Why Misdiagnosis Happens: CTS Isn't Always the Culprit
Arthritis — Inflammatory Joint Disease Mistaken for Nerve Pain
Cubital Tunnel Syndrome — The Elbow's Hidden Nerve Trap
Why an Accurate Diagnosis Is Critical
When to See a Specialist
Conclusion

What Is Carpal Tunnel Syndrome?

Carpal Tunnel Syndrome (CTS) occurs when the median nerve, which passes through the carpal tunnel in your wrist, becomes compressed. This compression interferes with nerve signaling and causes:

  • Tingling or numbness in the thumb, index, middle, and part of the ring finger
  • Weakness in hand grip or fine motor skills
  • Pain that may radiate up the forearm
  • Worsening symptoms during the night or with repetitive wrist activity

Common causes include repetitive wrist movements (e.g., typing), hormonal changes (e.g., pregnancy), obesity, diabetes, and hypothyroidism.
📚 Source: NIH - National Institute of Neurological Disorders

Why Misdiagnosis Happens: CTS Isn't Always the Culprit

CTS symptoms are non-specific meaning they overlap with other conditions that affect the hand, wrist, and elbow. Two conditions frequently misidentified as CTS are:

  1. Arthritis
  2. Cubital Tunnel Syndrome

Each has distinct causes and treatments, so getting the diagnosis right is essential.

1. Arthritis — Inflammatory Joint Disease Mistaken for Nerve Pain

Arthritis especially rheumatoid arthritis (RA) and osteoarthritis (OA) frequently affects the small joints of the hand and wrist. These conditions cause:

  • Joint inflammation, pain, and stiffness
  • Swelling and warmth around the joints
  • Decreased range of motion
  • Prolonged morning stiffness (30+ minutes)

Why Arthritis Gets Misdiagnosed as CTS:

  • Both involve wrist pain and hand dysfunction
  • Similar activity-related symptom aggravation
  • Overlapping signs like weakness and fatigue

Key Differences Between CTS and Arthritis:

Feature Carpal Tunnel Syndrome Arthritis (RA or OA)
Affected Area Median nerve (wrist tunnel) Joints (wrist, fingers)
Pain Type Numbness, tingling, shock-like sensations Achy pain, joint stiffness
Timing Worsens at night, with wrist overuse Morning stiffness, flare-ups
Response to Treatment Wrist brace, nerve decompression Anti-inflammatory meds, DMARDs, physical therapy
Visible Signs Rare Joint swelling, deformity, nodules (RA specific)

📚 Source: Arthritis Foundation

2. Cubital Tunnel Syndrome — The Elbow's Hidden Nerve Trap

Cubital Tunnel Syndrome (CuTS) involves compression of the ulnar nerve at the elbow, specifically near the medial epicondyle (your “funny bone”). It often mimics CTS but affects a different nerve and region.

Symptoms of Cubital Tunnel Syndrome:

  • Numbness or tingling in the ring and little fingers
  • Weak grip and reduced hand coordination
  • Aching pain near the inner elbow
  • Worsening symptoms with elbow flexion (e.g., phone use, sleeping with bent arms)

CTS vs. Cubital Tunnel Syndrome:

Feature Carpal Tunnel Syndrome Cubital Tunnel Syndrome
Nerve Involved Median nerve (wrist) Ulnar nerve (elbow)
Tingling Location Thumb to half of ring finger Ring and little fingers
Pain Origin Palm or wrist Elbow and outer hand
Aggravating Positions Wrist movement, typing Elbow bending, resting elbow on surfaces
Grip Issues General grip weakness Difficulty manipulating small objects

📚 Source: American Society for Surgery of the Hand

Why an Accurate Diagnosis Is Critical

Incorrectly assuming you have CTS may lead you to:

  • Wear ineffective splints
  • Delay medication for arthritis
  • Miss surgical windows for nerve release

Recommended tests for differential diagnosis include:

  • Nerve conduction studies / EMG
  • Ultrasound or MRI for joint evaluation
  • Physical exam maneuvers (e.g., Tinel's, Phalen's, Froment's sign)

📚 Source: Johns Hopkins Medicine

When to See a Specialist

See a neurologist, rheumatologist, or orthopedic hand specialist if:

  • Your symptoms persist >2 weeks despite rest
  • You experience hand weakness or muscle wasting
  • Pain or numbness interferes with sleep or daily activities
  • OTC meds or splints are not effective

Summary Table: CTS vs. Arthritis vs. Cubital Tunnel Syndrome

Condition Main Cause Key Symptoms
Carpal Tunnel Syndrome Median nerve compression Tingling in thumb/index/middle, night pain
Arthritis (RA or OA) Joint inflammation/degeneration Joint swelling, stiffness, dull wrist pain
Cubital Tunnel Syndrome Ulnar nerve compression at elbow Ring/little finger numbness, elbow pain

FAQs

Q1: Can arthritis cause carpal tunnel syndrome?

Yes. Inflammatory arthritis (e.g., RA) can swell wrist tissues, increasing pressure in the carpal tunnel.

Q2: How do I know if it's CTS or Cubital Tunnel Syndrome?

Focus on which fingers are affected. CTS: Thumb–ring. CuTS: Ring–little. Also, CTS worsens with wrist use, CuTS with elbow bending.

Q3: Should I wear a wrist brace even if I'm unsure of the diagnosis?

You can try a neutral wrist brace short term. If symptoms persist or worsen, consult a medical professional for a full evaluation.

Conclusion

Mislabeling symptoms as CTS when they stem from arthritis or ulnar nerve compression can lead to ineffective treatment and long-term damage. Get an accurate diagnosis with help from a licensed medical provider and pursue a treatment plan tailored to your true condition.

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Medical Disclaimer

This AI tool provides general information only and should not be used for diagnosis or treatment decisions. Always consult healthcare professionals for medical advice.

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